Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young.
Council on Cardiovascular Disease in the Young. American Heart Association Stroke Council. Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Monagle P, Chan AKC, Goldenberg NA, Ichord RN, Journeycake JM, Nowak-Gottl U, Vesely SK. Lexi-Drugs Online/Pediatric Lexi-Drugs Online, Enoxaparin,, Copyright © 1978-2008 Lexi-Comp, Inc, Hudson, OH 44236 Obtain blood for an PTT and PT 15 minutes after the administration of protamine.Įxcessive Protamine doses may worsen bleeding potential.ĭavid, M., et al. Patients with hypersensitivity to fish and those who have received protamine-containing insulin or previous protamine therapy may be at risk of hypersensitivity reactions. More rapid infusion may result in hypotension. Infusion rate should not exceed 5 mg/min. Protamine should be given IV over 10 minutes. Table 2-Protamine sulfate for immediate reversal Time since last heparin dose
The dose of protamine is based on the amount of heparin administered in the previous 2 hours using Table 2. If immediate reversal is required protamine sulfate will result in neutralization of heparin. It works by providing vitamin K that is needed for blood to clot normally in the body. Phytonadione is in a class of medications called vitamins. Termination of the IV infusion generally will terminate the anticoagulant effect. Why is this medication prescribed Phytonadione (vitamin K) is used to prevent bleeding in people with blood clotting problems or too little vitamin K in the body.
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